T. Eisenhaure

Altered interactions between circulating and tissue-resident CD8 T cells with the colonic mucosa define colitis associated with immune checkpoint inhibitors

This study identifies altered interactions between circulating and tissue-resident CD8 T cells with the colonic mucosa in immune checkpoint inhibitor-associated colitis using single-cell RNA sequencing and other multi-omics approaches.

Intrarenal myeloid subsets associated with kidney injury are comparable in mice and patients with lupus nephritis

This study identifies conserved myeloid subsets and disease-associated gene expression changes in kidney injury across lupus mouse models and human patients with lupus nephritis.

Differentiation of exhausted CD8 T cells after termination of chronic antigen stimulation stops short of achieving functional T cell memory

The paper shows that exhausted CD8 T cells do not fully recover functional memory after antigen removal in chronic HCV infection.

An efficient lentiviral CRISPRi approach to silence genes in primary human monocytes

This paper develops a lentiviral CRISPRi system to silence genes in primary human monocytes and demonstrates its use in studying gene function.

SLAMF6 deficiency augments tumor killing and skews towards an effector phenotype revealing it as a new T cell checkpoint

This study shows that SLAMF6 deficiency enhances T cell tumor-killing ability and shifts T cells toward an effector phenotype, suggesting SLAMF6 as a new immune checkpoint.

Multiplexed enrichment and genomic profiling of peripheral immune cell subsets on a microfluidic chip

This paper presents a microfluidic system for sorting and profiling immune cell subsets using RNA-seq, demonstrating its utility in identifying cell-specific disease signatures in lupus patients.