Author

L. T. Nieman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Assay:spatial transcriptomics· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Approach:deep learning· 1 Research Focus:differential expression· 1

Frequent Co-Authors

G. M. Boland· 2 shared K. H. Xu· 2 shared Y. Song· 2 shared A. K. Coley· 1 shared A. L. Tang· 1 shared A. Lawless· 1 shared A. Mehta· 1 shared A. Pankaj· 1 shared

Activity by Year

2023-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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2 shared papersImmunology

G. M. Boland

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Author profile →

3 papers

Recent·Most cited

Single Cell Spatial Transcriptomic Profiling Identifies a LINE1 Associated Disarrayed Immune Microenvironment in Hepatocellular Carcinoma

A. K. Coley, C. Nawrocki, B. K. Patel, A. Pankaj, Z. Guo, M. J. Emmett, E. R. Lang, Y. Song, K. H. Xu, C. R. Ferrone, V. Deshpande, L. T. Nieman, M. Aryee, J. W. Franses, D. T. Ting

This study uses single cell spatial transcriptomics to show LINE1 repeat RNA expression in HCC correlates with a disorganized immune microenvironment and poor patient survival.

bioRxiv · Dec 4, 2023 · PreprintCancer Biology

Immune Responses in Checkpoint Myocarditis Across Heart, Blood, and Tumor

S. M. Blum, D. A. Zlotoff, N. P. Smith, I. J. Kernin, S. Ramesh, L. Zubiri, J. Caplin, N. Samanta, S. C. Martin, A. Tirard, P. Sen, Y. Song, J. L. Barth, K. Slowikowski, M. Nasrallah, , A.-C. Villani

This study identifies immune cell types and biomarkers in irMyocarditis using single-cell RNA sequencing and TCR analysis across heart, blood, and tumor tissues.

bioRxiv · Sep 15, 2023 · PreprintImmunology

Spatial analysis of human lung cancer reveals organized immune hubs enriched for stem-like CD8 T cells and associated with immunotherapy response

J. H. Chen, L. T. Nieman, M. Spurrell, V. Jorgji, P. M. Richieri, K. H. Xu, R. Madhu, M. Parikh, I. Zamora, A. Mehta, C. S. Nabel, S. S. Freeman, J. D. Pirl, C. Lu, C. B. Meador, , N. Hacohen

The paper identifies immune hubs in lung cancer that are associated with better responses to PD-1-blockade immunotherapy and contain stem-like CD8 T cells.

bioRxiv · Apr 4, 2023Immunology