Author

K. R. McCarron

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

H. Elcocks· 2 shared H. J. Mortiboys· 2 shared M. J. Clague· 2 shared S. Urbe· 2 shared A. J. Brazel· 1 shared K. Husnjak· 1 shared M. Kaulich· 1 shared

Activity by Year

2022-2023 · peak 1/yr

Co-Author Collaboration Network

7 top collaborators · 21 mutual co-author links

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2 shared papersCell Biology

H. Elcocks

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2 papers

Recent·Most cited

The Parkinson's Disease related mutant VPS35 (D620N) amplifies the LRRK2 response to endolysosomal stress

K. R. McCarron, H. Elcocks, H. J. Mortiboys, S. Urbe, M. J. Clague

This study shows that the VPS35 D620N mutation enhances LRRK2 activity and amplifies its response to endolysosomal stress, leading to increased phosphorylation of RAB10 and RAB12.

bioRxiv · Dec 2, 2023Cell Biology

FBXL4 deficiency promotes mitophagy by elevating NIX.

H. Elcocks, A. J. Brazel, K. R. McCarron, M. Kaulich, K. Husnjak, H. J. Mortiboys, M. J. Clague, S. Urbe

This study identifies FBXL4 as a negative regulator of basal mitophagy through NIX stabilization, showing that its deficiency promotes mitophagy and suggesting MLN4924 as a potential therapeutic agent for mitochondrial diseases.

bioRxiv · Oct 11, 2022 · PreprintCell Biology