S. Urbe

A long-lived pool of PINK1 imparts a molecular memory of depolarisation-induced activity.

The paper shows that PINK1 accumulates on mitochondria under depolarisation, remains active, and can precondition subsequent PINK1 activation.

Rapid turnover of CTLA4 is associated with a complex architecture of reversible ubiquitylation.

The paper investigates CTLA4 turnover, showing ubiquitylation at K203 and K213 drives lysosomal degradation, with USP8 and HD-PTP modulating this process through distinct mechanisms.

The Parkinson's Disease related mutant VPS35 (D620N) amplifies the LRRK2 response to endolysosomal stress

This study shows that the VPS35 D620N mutation enhances LRRK2 activity and amplifies its response to endolysosomal stress, leading to increased phosphorylation of RAB10 and RAB12.

Whole organism and tissue specific analysis of pexophagy in Drosophila

This study uses Drosophila models to analyze pexophagy across tissues, showing tissue-specific regulation and identifying Hsc70-5 as a key regulator in neurons.

Microtubule association of TRIM3 revealed by differential extraction proteomics

The paper identifies TRIM3 as a novel microtubule-binding protein using differential extraction proteomics and shows its role in acetylated tubulin accumulation.

ISGylation-independent protection of cell growth by USP18 following interferon stimulation

This study shows USP18 suppresses ISG15 E1 enzyme expression and cell growth inhibition in interferon-stimulated cells independently of its deubiquitylase activity.

Segregation of pathways leading to pexophagy

The paper identifies MLN4924 and CMPD-39 as activators of pexophagy, showing distinct pathways mediated by BNIP3L/NIX and NBR1 respectively.

FBXL4 deficiency promotes mitophagy by elevating NIX.

This study identifies FBXL4 as a negative regulator of basal mitophagy through NIX stabilization, showing that its deficiency promotes mitophagy and suggesting MLN4924 as a potential therapeutic agent for mitochondrial diseases.

The deubiquitylase USP31 controls the Chromosomal Passenger Complex and spindle dynamics

This study identifies USP31 as a deubiquitylase regulating the chromosomal passenger complex and spindle dynamics during mitosis, leading to chromosomal segregation errors and polyploidy upon depletion.

Benchmarking a highly selective USP30 inhibitor for enhancement of mitophagy and pexophagy.

This paper benchmarks a selective USP30 inhibitor, compound 39, showing it enhances mitophagy and pexophagy in cell models.

USP28 deletion and small molecule inhibition destabilises c-Myc and elicits regression of squamous cell lung carcinoma

This study shows that deleting or inhibiting USP28 reduces c-Myc levels and causes regression of lung squamous cell carcinoma in mice and human xenografts.

A novel USP30 inhibitor recapitulates genetic loss of USP30 and sets the trigger for PINK1-PARKIN amplification of mitochondrial ubiquitylation.

The paper identifies a USP30 inhibitor that mimics genetic loss of USP30, revealing its role in regulating mitochondrial ubiquitylation and mitophagy through TOM complex components.

The deubiquitylase USP9X controls ribosomal stalling

This study identifies USP9X as a deubiquitylase that regulates ZNF598 stability, impacting ribosomal quality control through modulation of di-ribosome resolution.