Author

M. J. Clague

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 12 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 12 Research Focus:cell signaling & trafficking· 11 Organism:human· 10 Assay:proteomics· 9 Research Focus:cell type annotation· 8 Research Focus:cancer & tumor microenvironment· 3 Research Focus:drug response / drug discovery· 3 Organism:mouse· 3

Frequent Co-Authors

S. Urbe· 12 shared F. G. Barone· 4 shared A. Pinto-Fernandez· 3 shared B. M. Kessler· 3 shared D. Komander· 3 shared H. Elcocks· 3 shared S. Ioannidis· 3 shared A. Behrens· 2 shared

Activity by Year

2018-2023 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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12 shared papersCell Biology

S. Urbe

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Author profile →

13 papers

Recent·Most cited

Rapid turnover of CTLA4 is associated with a complex architecture of reversible ubiquitylation.

P. Y. Tey, A. Dufner, K.-P. Knobeloch, J. N. Pruneda, M. J. Clague, S. Urbe

The paper investigates CTLA4 turnover, showing ubiquitylation at K203 and K213 drives lysosomal degradation, with USP8 and HD-PTP modulating this process through distinct mechanisms.

bioRxiv · Dec 31, 2023Cell Biology

The Parkinson's Disease related mutant VPS35 (D620N) amplifies the LRRK2 response to endolysosomal stress

K. R. McCarron, H. Elcocks, H. J. Mortiboys, S. Urbe, M. J. Clague

This study shows that the VPS35 D620N mutation enhances LRRK2 activity and amplifies its response to endolysosomal stress, leading to increased phosphorylation of RAB10 and RAB12.

bioRxiv · Dec 2, 2023Cell Biology

Whole organism and tissue specific analysis of pexophagy in Drosophila

F. G. Barone, M. Marcello, S. Urbe, N. Sanchez-Soriano, M. J. Clague

This study uses Drosophila models to analyze pexophagy across tissues, showing tissue-specific regulation and identifying Hsc70-5 as a key regulator in neurons.

bioRxiv · Nov 17, 2023 · PreprintCell Biology

Microtubule association of TRIM3 revealed by differential extraction proteomics

H. Glover, M. Mendes, J. Gomes-Neto, E. V. Ruscilowicz-Jones, D. Rigden, G. Dittmar, S. Urbe, M. J. Clague

The paper identifies TRIM3 as a novel microtubule-binding protein using differential extraction proteomics and shows its role in acetylated tubulin accumulation.

bioRxiv · Jul 27, 2023Cell Biology

ISGylation-independent protection of cell growth by USP18 following interferon stimulation

A. Clancy, E. V. Rusilowicz-Jones, I. Wallace, K. N. Swatek, S. Urbe, M. J. Clague

This study shows USP18 suppresses ISG15 E1 enzyme expression and cell growth inhibition in interferon-stimulated cells independently of its deubiquitylase activity.

bioRxiv · Jul 21, 2023 · PreprintCell Biology

Segregation of pathways leading to pexophagy

F. G. Barone, S. Urbe, M. J. Clague

The paper identifies MLN4924 and CMPD-39 as activators of pexophagy, showing distinct pathways mediated by BNIP3L/NIX and NBR1 respectively.

bioRxiv · Nov 8, 2022Cell Biology

FBXL4 deficiency promotes mitophagy by elevating NIX.

H. Elcocks, A. J. Brazel, K. R. McCarron, M. Kaulich, K. Husnjak, H. J. Mortiboys, M. J. Clague, S. Urbe

This study identifies FBXL4 as a negative regulator of basal mitophagy through NIX stabilization, showing that its deficiency promotes mitophagy and suggesting MLN4924 as a potential therapeutic agent for mitochondrial diseases.

bioRxiv · Oct 11, 2022 · PreprintCell Biology

The deubiquitylase USP31 controls the Chromosomal Passenger Complex and spindle dynamics

E. Bertsoulaki, H. L. Glover, J. I. Gomes-Neto, B. Pizer, H. Maiato, S. Urbe, M. J. Clague

This study identifies USP31 as a deubiquitylase regulating the chromosomal passenger complex and spindle dynamics during mitosis, leading to chromosomal segregation errors and polyploidy upon depletion.

bioRxiv · Aug 17, 2022 · PreprintCell Biology

Benchmarking a highly selective USP30 inhibitor for enhancement of mitophagy and pexophagy.

E. V. Rusilowicz-Jones, F. G. Barone, F. Martins Lopes, E. Stephen, H. Mortiboys, S. Urbe, M. J. Clague

This paper benchmarks a selective USP30 inhibitor, compound 39, showing it enhances mitophagy and pexophagy in cell models.

bioRxiv · Apr 28, 2021Cell Biology

USP28 deletion and small molecule inhibition destabilises c-Myc and elicits regression of squamous cell lung carcinoma

E. J. Ruiz, A. Pinto-Fernandez, A. P. Turnbull, L. Lan, T. M. Charlton, H. C. Scott, A. Damianou, G. Vere, E. M. Riising, C. Da Costa, W. W. Krajewski, D. Guerin, J. Kearns, S. Ioannidis, M. Katz, , A. Behrens

This study shows that deleting or inhibiting USP28 reduces c-Myc levels and causes regression of lung squamous cell carcinoma in mice and human xenografts.

bioRxiv · Nov 17, 2020Cancer Biology

A novel USP30 inhibitor recapitulates genetic loss of USP30 and sets the trigger for PINK1-PARKIN amplification of mitochondrial ubiquitylation.

E. Rusilowicz-Jones, J. Jardine, A. Kallinos, A. Pinto-Fernandez, F. Guenther, M. Giurrandino, F. G. Barone, K. McCarron, C. J. Burke, A. Murad, A. Martinez, E. Marcassa, M. Gersch, A. Buckmelter, K. Kayser-Bricker, , M. J. Clague

The paper identifies a USP30 inhibitor that mimics genetic loss of USP30, revealing its role in regulating mitochondrial ubiquitylation and mitophagy through TOM complex components.

Life Science Alliance · Jul 7, 2020Peer-reviewedCell Biology

The deubiquitylase USP9X controls ribosomal stalling

A. Clancy, C. Heride, A. Pinto-Fernandez, A. Kallinos, K. Kayser-Bricker, W. Wang, V. Smith, H. Elcocks, S. Davis, S. Fessler, C. McKinnon, M. Katz, T. Hammonds, N. P. Jones, J. O'Connell, , M. J. Clague

This study identifies USP9X as a deubiquitylase that regulates ZNF598 stability, impacting ribosomal quality control through modulation of di-ribosome resolution.

bioRxiv · Apr 15, 2020Cell Biology

Basal mitophagy is widespread in Drosophila but minimally affected by loss of Pink1 or parkin

J. J. Lee, A. Sanchez-Martinez, A. Martinez Zarate, C. Beninca, U. Mayor, M. J. Clague, A. J. Whitworth

The paper investigates the role of PINK1 and parkin in basal mitophagy in Drosophila, finding no significant impact on basal mitophagy despite locomotor defects and dopaminergic neuron loss.

bioRxiv · Jan 12, 2018Cell Biology