Author

K. Husnjak

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Research Focus:cell signaling & trafficking· 3 Assay:proteomics· 3 Research Focus:drug response / drug discovery· 2 Approach:genetic perturbation / CRISPR· 2 Research Focus:cell type annotation· 1 Assay:CRISPR screen· 1

Frequent Co-Authors

M. Kaulich· 3 shared I. Dikic· 2 shared M. Wegner· 2 shared P. Grumati· 2 shared S. Schaubeck· 2 shared A. Balakrishnan· 1 shared A. Ciulli· 1 shared A. Correa-Saez· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersCell Biology

M. Kaulich

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

The function of ER-phagy receptors is regulated through phosphorylation-dependent ubiquitination pathways

R. Berkane, H. Ho-Xuan, M. Glogger, P. Sanz-Martinez, L. Brunello, T. Glaesner, S. K. Kuncha, K. Holzhueter, S. Cano-Franco, V. Buonomo, P. Cabrerizo-Poveda, A. Balakrishnan, M. Misra, T. Juretschke, K. Husnjak, , A. Stolz

This study identifies CK2-dependent phosphorylation and ubiquitination as essential for FAM134B and FAM134C-driven ER-phagy activation during mTOR inhibition.

bioRxiv · Feb 27, 2023Cell Biology

Targeted protein degradation via intramolecular bivalent glues

O. Hsia, M. Hinterndorfer, A. D. Cowan, K. Iso, T. Ishida, R. Sundaramoorthy, M. A. Nakasone, H. Imrichova, C. Schatz, A. Rukavina, K. Husnjak, M. Wegner, A. Correa-Saez, C. Craigon, R. Casement, , A. Ciulli

This paper introduces intramolecular bivalent glues (IBGs) as a new method for targeted protein degradation, showing they enhance ubiquitination by bridging protein domains and improving degradation efficiency.

bioRxiv · Feb 14, 2023Biochemistry

FBXL4 deficiency promotes mitophagy by elevating NIX.

H. Elcocks, A. J. Brazel, K. R. McCarron, M. Kaulich, K. Husnjak, H. J. Mortiboys, M. J. Clague, S. Urbe

This study identifies FBXL4 as a negative regulator of basal mitophagy through NIX stabilization, showing that its deficiency promotes mitophagy and suggesting MLN4924 as a potential therapeutic agent for mitochondrial diseases.

bioRxiv · Oct 11, 2022 · PreprintCell Biology

N4BP1 is dimerization-dependent linear ubiquitin reader regulating TNFR1 signalling through linear ubiquitin binding and Caspase-8-mediated processing

K. W. Kliza, W. Song, I. Pinzuti, S. Schaubeck, S. Kunzelmann, D. Kuntin, A. Fornili, A. Pandini, K. Hofmann, J. Garnett, B. Stieglitz, K. Husnjak

This study identifies N4BP1 as a dimerization-dependent linear ubiquitin reader that regulates TNFR1 signaling by modulating NF-κB and apoptosis pathways.

bioRxiv · Nov 2, 2021 · PreprintBiochemistry

Combinatorial CRISPR screening reveals functional buffering in autophagy

V. Diehl, M. Wegner, P. Grumati, K. Husnjak, S. Schaubeck, A. Gubas, V. J. Shah, F. Langschied, A. Kalousi, I. Ebersberger, I. Dikic, M. Kaulich

This study uses combinatorial CRISPR screening to identify gene interactions in autophagy, revealing functional buffering and redundant gene circuits.

bioRxiv · Jul 28, 2020Cell Biology