The antipsychotic medications aripiprazole, brexpiprazole and cariprazine are off-target respiratory chain complex I inhibitors
R. E. Hardy, I. Chung, Y. Yu, S. H. Y. Loh, N. Morone, C. Soleilhavoup, M. Travaglio, R. Serreli, L. Panman, K. Cain, J. Hirst, L. M. Martins, M. MacFarlane, K. R. Pryde
This study shows that antipsychotics aripiprazole, brexpiprazole, and cariprazine inhibit mitochondrial respiratory complex I, causing toxicity and movement disorders.
bioRxiv · Apr 2, 2023Pharmacology & Toxicology