Chemoproteomics of microbiota metabolites reveals small-molecule agonists for orphan receptor GPRC5A
X. Zhao, K. R. Stein, V. Chen, M. E. Griffin, H. C. Hang
The paper identifies small-molecule agonists for the orphan receptor GPRC5A using chemoproteomics of microbiota metabolites, revealing bacterial sources and key residues involved in ligand binding.
bioRxiv · Dec 16, 2021 · PreprintBiochemistry