T. W. Geisbert

A Single-shot ChAd3 Vaccine Provides Protection from Intramuscular and Aerosol Sudan Virus Exposure

A single dose of ChAd3-SUDV vaccine protected macaques from lethal SUDV challenge via parenteral and aerosol routes.

A highly attenuated Vesiculovax vaccine rapidly protects nonhuman primates against lethal Marburg virus challenge

This paper shows a highly attenuated rVSV-based vaccine protects nonhuman primates against lethal Marburg virus challenge when administered up to 1 week before exposure.

Natural history of nonhuman primates after conjunctival exposure to Ebola virus

This study examines the natural history of Ebola virus infection in nonhuman primates after conjunctival exposure, finding that lower doses result in delayed disease and reduced mortality.

Rapid and Durable Protection Against Marburg Virus with a Single-Shot ChAd3-MARV GP Vaccine

A single-shot ChAd3-MARV vaccine provided rapid and durable protection against lethal Marburg virus infection in macaques, with antigen-specific antibodies correlating strongly with immunity.

Protective pan-ebolavirus combination therapy by two multifunctional human antibodies

This paper develops a therapeutic cocktail of two human antibodies that protect against multiple ebolaviruses in non-human primates and reveals their molecular mechanisms.

Functional cooperativity mediated by rationally selected combinations of human monoclonal antibodies targeting the henipavirus receptor binding protein

This study identifies human monoclonal antibodies that neutralize HeV and NiV by targeting distinct antigenic sites on the receptor binding protein and demonstrates their cooperative binding and synergistic therapeutic effects.

Use of convalescent serum reduces severity of COVID-19 in nonhuman primates

This study shows that convalescent sera with high neutralizing antibody titers reduce SARS-CoV-2 viral load and disease severity in African green monkeys.

LY-CoV555, a rapidly isolated potent neutralizing antibody, provides protection in a non-human primate model of SARS-CoV-2 infection

LY-CoV555, an anti-spike antibody from a convalescent COVID-19 patient, neutralizes SARS-CoV-2 and protects non-human primates against infection.

Alpha-1-antitrypsin and its variant-dependent role in COVID-19 pathogenesis

This study investigates the role of alpha-1-antitrypsin in inhibiting SARS-CoV-2 entry and shows variant-dependent effects on its ability to block different viral strains.

Establishment of an African green monkey model for COVID-19

This study establishes an African green monkey model for COVID-19, showing high SARS-CoV-2 replication and severe respiratory disease with lower viral doses than in other NHP species.

Marburg and Ebola virus infections elicit a complex, muted inflammatory state in bats

This study investigates how Marburg and Ebola viruses elicit a complex, muted inflammatory response in bats, revealing mechanisms that may explain their non-pathogenicity in these animals.

Prior vaccination with the rVSV-ZEBOV vaccine does not interfere with but improves the efficacy of postexposure antibody treatment in nonhuman primates exposed to Ebola virus

Two-antibody pan-ebolavirus cocktail confers broad therapeutic protection in ferrets and nonhuman primates

This paper demonstrates that a two-antibody cocktail (MBP134AF) provides broad therapeutic protection against multiple ebolaviruses in ferrets and nonhuman primates.