Author

K. Sishtla

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

T. W. Corson· 3 shared B. Park· 2 shared T. Shetty· 2 shared A. Motolani· 1 shared A. Muniyandi· 1 shared F. Shah· 1 shared J. H. Wikel· 1 shared L. Prabhu· 1 shared

Activity by Year

2018-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersPharmacology & Toxicology

T. W. Corson

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3 papers

Recent·Most cited

PRMT5 is a therapeutic target in choroidal neovascularization

A. Muniyandi, M. Martin, M. Sun, K. Sishtla, N. R. Jensen, A. Motolani, X. Qi, M. E. Boulton, L. Prabhu, T. Lu, T. W. Corson

This study identifies PRMT5 as a therapeutic target for neovascular age-related macular degeneration by showing its inhibition reduces NF-κB activity and angiogenic properties in ocular endothelial cells.

bioRxiv · Mar 30, 2022Pharmacology & Toxicology

Heme synthesis inhibition blocks angiogenesis via mitochondrial dysfunction

T. Shetty, K. Sishtla, B. Park, M. J. Repass, T. W. Corson

This study shows that inhibiting heme synthesis disrupts mitochondrial function in endothelial cells, leading to impaired angiogenesis.

bioRxiv · Nov 9, 2019Cell Biology

Ref-1/APE1 inhibition with novel small molecules blocks ocular neovascularization

S. P. Sheik Pran Babu, K. Sishtla, R. S. Sulaiman, B. Park, T. Shetty, F. Shah, M. L. Fishel, J. H. Wikel, M. R. Kelley, T. W. Corson

This paper develops and tests new Ref-1/APE1 inhibitors, showing they block ocular neovascularization in vitro, ex vivo, and in a mouse model.

bioRxiv · Jun 23, 2018Pharmacology & Toxicology