T. Shetty

Heme synthesis inhibition blocks angiogenesis via mitochondrial dysfunction

This study shows that inhibiting heme synthesis disrupts mitochondrial function in endothelial cells, leading to impaired angiogenesis.

Ref-1/APE1 inhibition with novel small molecules blocks ocular neovascularization

This paper develops and tests new Ref-1/APE1 inhibitors, showing they block ocular neovascularization in vitro, ex vivo, and in a mouse model.