K. Takanobu

Carcinogenicity and testicular toxicity of 2-bromopropane in a 26-week inhalation study using the rasH2 mouse model

This study demonstrates that 2-bromopropane induces lung tumors and testicular toxicity in rasH2 mice after 26 weeks of inhalation exposure.

Pulmonary dust foci as rat pneumoconiosis lesion induced by titanium dioxide nanoparticles in 13-week inhalation study

This study investigates pulmonary lesions in rats exposed to titanium dioxide nanoparticles, identifying a new lesion type called pulmonary dust foci associated with pneumoconiosis-like effects.

Dose-response relationship of pulmonary disorders by inhalation exposure to cross-linked water-soluble acrylic acid polymers in F344 rats

This study investigates the dose-response relationship of pulmonary disorders caused by inhalation of CWAAP-A in rats, finding a LOAEC of 1 mg/m3 and reversible damage at 1 mg/m3 with gender differences in recovery.

Lack of pulmonary fibrogenicity and carcinogenicity of titanium dioxide nanoparticles in 26-week inhalation study in rasH2 mouse model

This study shows titanium dioxide nanoparticles do not cause lung fibrosis or cancer in rasH2 mice after 26 weeks of inhalation exposure up to 32 mg/m3.

Pathological characteristics of pulmonary toxicity in F344 rats exposed by inhalation to cross-linked water-soluble acrylic acid polymers

This study examines lung damage in rats exposed to cross-linked water-soluble acrylic acid polymers (CWAAPs) via inhalation and intratracheal instillation, finding similar pathological outcomes between exposure routes.