Dose-response relationship of pulmonary disorders by inhalation exposure to cross-linked water-soluble acrylic acid polymers in F344 rats
T. Takeda, S. Yamano, Y. Goto, S. Hirai, Y. Furukawa, Y. Kikuchi, K. Misumi, M. Suzuki, K. Takanobu, H. Senoh, M. Saito, H. Kondo, G. Daghlian, Y. K. Hong, Y. Yoshimatsu, , Y. Umeda
This study investigates the dose-response relationship of pulmonary disorders caused by inhalation of CWAAP-A in rats, finding a LOAEC of 1 mg/m3 and reversible damage at 1 mg/m3 with gender differences in recovery.
bioRxiv · Dec 26, 2021Pharmacology & Toxicology