Y. Furukawa

Stability of N-type inactivation and the coupling between N-type and C-type inactivation in the Aplysia Kv1 channel

This study investigates N-type and C-type inactivation in the Aplysia Kv1 channel, showing that N-C coupling affects inactivation recovery and that Zn2+ accelerates C-type inactivation.

Microbiome ssRNA as an environmental cue to activate TLR13-dependent tissue-protective programs in CD5Lhi hepatic macrophages

The paper shows that microbiome ssRNA activates TLR13 in hepatic macrophages to drive tissue-protective responses, leading to resistance against acute liver injury in Rnaset2-/- mice.

TLR7/8 stress response drives histiocytosis in SLC29A3 disorders

This study identifies TLR7/8 as drivers of histiocytosis in SLC29A3 disorders by responding to lysosomal nucleoside stress and enhancing monocyte proliferation and phagocyte maturation.

Quantitative analysis of calcium oxalate monohydrate and dihydrate for elucidating the formation mechanism of calcium oxalate kidney stones

This paper quantitatively analyzes calcium oxalate monohydrate and dihydrate in kidney stones using FTIR, PXRD, and micro-CT to understand their formation mechanisms.

Polycomb repressive complex 1.1 coordinates homeostatic and emergency myelopoiesis

This study identifies PRC1.1 as a regulator of homeostatic and emergency myelopoiesis, showing its role in balancing myeloid differentiation and preventing transformation.

Pulmonary dust foci as rat pneumoconiosis lesion induced by titanium dioxide nanoparticles in 13-week inhalation study

This study investigates pulmonary lesions in rats exposed to titanium dioxide nanoparticles, identifying a new lesion type called pulmonary dust foci associated with pneumoconiosis-like effects.

Adenylate kinase 1 overexpression increases locomotor activity in medaka fish

This study shows that overexpressing adenylate kinase 1 in medaka fish increases locomotor activity, which is temperature-dependent.

Dose-response relationship of pulmonary disorders by inhalation exposure to cross-linked water-soluble acrylic acid polymers in F344 rats

This study investigates the dose-response relationship of pulmonary disorders caused by inhalation of CWAAP-A in rats, finding a LOAEC of 1 mg/m3 and reversible damage at 1 mg/m3 with gender differences in recovery.

Lack of pulmonary fibrogenicity and carcinogenicity of titanium dioxide nanoparticles in 26-week inhalation study in rasH2 mouse model

This study shows titanium dioxide nanoparticles do not cause lung fibrosis or cancer in rasH2 mice after 26 weeks of inhalation exposure up to 32 mg/m3.

Fast in-vitro screening of FLT3-ITD inhibitors using silkworm-baculovirus protein expression system

The paper expresses and purifies FLT3-ITD protein using a silkworm-baculovirus system and identifies two potent inhibitors through an inhibition assay.

Pathological characteristics of pulmonary toxicity in F344 rats exposed by inhalation to cross-linked water-soluble acrylic acid polymers

This study examines lung damage in rats exposed to cross-linked water-soluble acrylic acid polymers (CWAAPs) via inhalation and intratracheal instillation, finding similar pathological outcomes between exposure routes.