Author

S. Hirai

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Pharmacology & Toxicology· 3 Immunology· 1 Pathology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 4 Organism:rat· 3 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Assay:scATAC-seq· 1

Frequent Co-Authors

H. Kondo· 4 shared H. Senoh· 4 shared K. Misumi· 4 shared K. Takanobu· 4 shared M. Saito· 4 shared M. Suzuki· 4 shared S. Yamano· 4 shared T. Takeda· 4 shared

Activity by Year

2021-2022 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersPharmacology & Toxicology

H. Kondo

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Pulmonary dust foci as rat pneumoconiosis lesion induced by titanium dioxide nanoparticles in 13-week inhalation study

S. Yamano, Y. Goto, T. Takeda, S. Hirai, Y. Furukawa, Y. Kikuchi, T. Kasai, K. Misumi, M. Suzuki, K. Takanobu, H. Senoh, M. Saito, H. Kondo, Y. Umeda

This study investigates pulmonary lesions in rats exposed to titanium dioxide nanoparticles, identifying a new lesion type called pulmonary dust foci associated with pneumoconiosis-like effects.

bioRxiv · Mar 31, 2022Pathology

Dose-response relationship of pulmonary disorders by inhalation exposure to cross-linked water-soluble acrylic acid polymers in F344 rats

T. Takeda, S. Yamano, Y. Goto, S. Hirai, Y. Furukawa, Y. Kikuchi, K. Misumi, M. Suzuki, K. Takanobu, H. Senoh, M. Saito, H. Kondo, G. Daghlian, Y. K. Hong, Y. Yoshimatsu, , Y. Umeda

This study investigates the dose-response relationship of pulmonary disorders caused by inhalation of CWAAP-A in rats, finding a LOAEC of 1 mg/m3 and reversible damage at 1 mg/m3 with gender differences in recovery.

bioRxiv · Dec 26, 2021Pharmacology & Toxicology

Lack of pulmonary fibrogenicity and carcinogenicity of titanium dioxide nanoparticles in 26-week inhalation study in rasH2 mouse model

S. Yamano, T. Takeda, Y. Goto, S. Hirai, Y. Furukawa, Y. Kikuchi, T. Kasai, K. Misumi, M. Suzuki, K. Takanobu, H. Senoh, M. Saito, H. Kondo, Y. Umeda

This study shows titanium dioxide nanoparticles do not cause lung fibrosis or cancer in rasH2 mice after 26 weeks of inhalation exposure up to 32 mg/m3.

bioRxiv · Dec 23, 2021Pharmacology & Toxicology

Pathological characteristics of pulmonary toxicity in F344 rats exposed by inhalation to cross-linked water-soluble acrylic acid polymers

S. Yamano, T. Takeda, Y. Goto, S. Hirai, Y. Furukawa, Y. Kikuchi, K. Misumi, M. Suzuki, K. Takanobu, H. Senoh, M. Saito, H. Kondo, Y. Kobashi, K. Okamoto, T. Kishimoto, Y. Umeda

This study examines lung damage in rats exposed to cross-linked water-soluble acrylic acid polymers (CWAAPs) via inhalation and intratracheal instillation, finding similar pathological outcomes between exposure routes.

bioRxiv · Nov 13, 2021Pharmacology & Toxicology

Integrative analysis of scRNAs-seq and scATAC-seq revealed transit-amplifying thymic epithelial cells expressing autoimmune regulator

T. Akiyama, T. MIyao, M. Miyauchi, T. Kelly, T. W. Terooatea, T. Ishikawa, E. Oh, S. Hirai, K. Horie, Y. Takakura, H. Ohki, M. Hayama, Y. Maruyama, T. Seki, H. Yabukami, , N. Akiyama

The paper identifies transit-amplifying thymic epithelial cells expressing Aire and CD80 through integrative scRNA-seq and scATAC-seq analysis.

bioRxiv · Oct 4, 2021Immunology