T. Takeda

Identification of pharmacological inducers of a reversible hypometabolic state for whole organ preservation

The paper identifies SNC80 as a drug that reversibly slows metabolism in Xenopus and demonstrates its cross-species applicability in human organs-on-chips and porcine organs.

Simple ways to avoid collecting highly 137Cs-contaminated Aralia elata buds

The paper evaluates environmental factors affecting 137Cs contamination in Aralia elata buds to provide strategies for avoiding highly contaminated specimens.

Pacsin 2-dependent N-cadherin internalization regulates the migration behaviour of malignant cancer cells

This study shows that pacsin 2 regulates N-cadherin internalization, affecting collective migration of bladder cancer cells.

Pulmonary dust foci as rat pneumoconiosis lesion induced by titanium dioxide nanoparticles in 13-week inhalation study

This study investigates pulmonary lesions in rats exposed to titanium dioxide nanoparticles, identifying a new lesion type called pulmonary dust foci associated with pneumoconiosis-like effects.

A Jacalin-like lectin-domain-containing protein of Sclerospora graminicola act as an apoplastic virulence effector in plant-oomycete interactions

This study identifies SgJRL proteins from Sclerospora graminicola as apoplastic virulence effectors that suppress plant defense responses during infection.

Apoplastic CBM1-interacting proteins bind conserved carbohydrate binding module 1 motifs in fungal hydrolases to counter pathogen invasion

The paper identifies OsCBMIP, a rice protein that binds to fungal CBM1 domains in xylanases, inhibiting their activity and enhancing rice defense against M. oryzae.

Dose-response relationship of pulmonary disorders by inhalation exposure to cross-linked water-soluble acrylic acid polymers in F344 rats

This study investigates the dose-response relationship of pulmonary disorders caused by inhalation of CWAAP-A in rats, finding a LOAEC of 1 mg/m3 and reversible damage at 1 mg/m3 with gender differences in recovery.

Lack of pulmonary fibrogenicity and carcinogenicity of titanium dioxide nanoparticles in 26-week inhalation study in rasH2 mouse model

This study shows titanium dioxide nanoparticles do not cause lung fibrosis or cancer in rasH2 mice after 26 weeks of inhalation exposure up to 32 mg/m3.

Pathological characteristics of pulmonary toxicity in F344 rats exposed by inhalation to cross-linked water-soluble acrylic acid polymers

This study examines lung damage in rats exposed to cross-linked water-soluble acrylic acid polymers (CWAAPs) via inhalation and intratracheal instillation, finding similar pathological outcomes between exposure routes.

A genetically linked pair of NLR immune receptors show contrasting patterns of evolution

This paper studies the evolution of a rice NLR gene pair, showing that the sensor NLR undergoes dynamic domain integration under balancing selection, while the helper NLR remains functionally conserved under purifying selection.

Imaging-based evaluation of pathogenicity by novel DNM2 variants associated with centronuclear myopathy

The paper evaluates the pathogenicity of novel DNM2 variants associated with centronuclear myopathy using an in cellulo imaging assay of T-tubule-like structures.

The blast pathogen effector AVR-Pik binds and stabilizes rice heavy metal-associated (HMA) proteins to co-opt their function in immunity

This study shows that the fungal effector AVR-Pik binds and stabilizes rice HMA proteins, co-opting their function to suppress immunity, while also triggering immunity in plants with integrated HMA domains in NLRs.

Dynamic clustering of dynamin-amphiphysin rings regulates membrane constriction and fission coupled with GTP hydrolysis

This study uses EM and HS-AFM to show dynamin-amphiphysin rings cluster during GTP hydrolysis, driving membrane constriction and fission through a novel clusterase mechanism.