M. Saito

Possible acquisition and molecular evolution of vpu genes inferred from comprehensive sequence analysis of human and simian immunodeficiency viruses

This study analyzes Vpu gene sequences from HIV and SIV to classify them into four types and infer their evolutionary origins and divergence.

Spatial and Temporal Resolution of Cyanobacterial Bloom Chemistry Reveals an Open-Ocean Trichodesmium thiebautii as a Talented Producer of Specialized Metabolites

The paper identifies a consistent specialized metabolome in Trichodesmium thiebautii blooms and isolates a new macrocyclic compound, suggesting potential ecological roles for these metabolites.

Vitamin B12 conveys a protective advantage to phycosphere-associated bacteria at high temperatures

This study shows that vitamin B12 provides a growth advantage to marine bacteria at high temperatures, with implications for microbial community dynamics under climate change.

Induction of plant disease resistance by mixed oligosaccharide elicitors prepared from plant cell wall and crustacean shells

This study compares the elicitor activities of different oligosaccharides from plant cell walls and crustacean shells, showing that a mixture enhances disease resistance in tomato without inhibiting growth.

Partially hydrolyzed guar gum attenuates the symptoms of SARS-CoV-2 infection through gut microbiota modulation in an animal model.

This study shows that partially hydrolyzed guar gum improves survival and reduces weight loss in SARS-CoV-2 infected Syrian hamsters by modulating gut microbiota and metabolites.

Identification of differentially recognized T cell epitopes in the spectrum of Mtb infection

The paper identifies differentially recognized T cell epitopes in Mtb infection stages using a proteome-wide screen and Fluorospot assay, revealing epitopes specific to active TB and potential vaccine targets.

Diversification of Polynucleotide Kinase Clp1 Family Proteins and Their Possible Origins in Eukaryotic Evolution

The paper identifies the evolutionary origin of Clp1 family proteins by analyzing genome data from 358 eukaryotic species and finds that protist Euglenozoa have multiple Clp1 family genes with unique domain structures.

Carcinogenicity and testicular toxicity of 2-bromopropane in a 26-week inhalation study using the rasH2 mouse model

This study demonstrates that 2-bromopropane induces lung tumors and testicular toxicity in rasH2 mice after 26 weeks of inhalation exposure.

Lymphoma cells are circulating in blood of Enzootic Bovine Leukosis and clonality value of virus-infected cells is a useful information for the diagnostic test

The paper demonstrates that clonality values of BLV-infected cells in blood can reliably detect Enzootic Bovine Leukosis and are useful for diagnostic testing.

Diagnosis and early prediction of lymphoma using high-throughput clonality analysis of bovine leukemia virus-infected cells

This study evaluates RAISING-CLOVA's ability to detect clonality in BLV-infected cells, showing high sensitivity and specificity in distinguishing EBL from non-EBL cattle and confirming its utility for early detection.

Quantitative environmental DNA metabarcoding shows high potential as a novel approach to quantitatively assess fish community

This study evaluates the qMiSeq approach for quantitative eDNA metabarcoding to assess fish communities by comparing eDNA concentrations with capture survey results.

Pulmonary dust foci as rat pneumoconiosis lesion induced by titanium dioxide nanoparticles in 13-week inhalation study

This study investigates pulmonary lesions in rats exposed to titanium dioxide nanoparticles, identifying a new lesion type called pulmonary dust foci associated with pneumoconiosis-like effects.

Peripheral blood T-cell deficiency and hyperinflammatory monocyte responses associate with MAC lung disease

The paper investigates immune responses in individuals with MAC lung disease, finding reduced T-cell responses and hyperinflammatory monocyte activity.

Microbiomes of the bloom-forming alga, Phaeocystis globosa, are stable, consistently recruited communities with symbiotic and opportunistic modes

This study investigates the stability and function of microbiomes associated with Phaeocystis globosa blooms, revealing consistent bacterial communities and their impact on growth under different nutrient conditions.

Dose-response relationship of pulmonary disorders by inhalation exposure to cross-linked water-soluble acrylic acid polymers in F344 rats

This study investigates the dose-response relationship of pulmonary disorders caused by inhalation of CWAAP-A in rats, finding a LOAEC of 1 mg/m3 and reversible damage at 1 mg/m3 with gender differences in recovery.

Lack of pulmonary fibrogenicity and carcinogenicity of titanium dioxide nanoparticles in 26-week inhalation study in rasH2 mouse model

This study shows titanium dioxide nanoparticles do not cause lung fibrosis or cancer in rasH2 mice after 26 weeks of inhalation exposure up to 32 mg/m3.

Pathological characteristics of pulmonary toxicity in F344 rats exposed by inhalation to cross-linked water-soluble acrylic acid polymers

This study examines lung damage in rats exposed to cross-linked water-soluble acrylic acid polymers (CWAAPs) via inhalation and intratracheal instillation, finding similar pathological outcomes between exposure routes.

Lysophosphatidylcholine acyltransferase 1 controls the mitochondrial reactive oxygen species generation and survival of the retinal photoreceptor cells

This study shows that Lpcat1 deletion causes photoreceptor-specific apoptosis and increased mitochondrial ROS in mice, highlighting its role in lipid metabolism and retinal health.

Milk casein prevents inactivation effect of black tea galloylated theaflavins on SARS-CoV-2 in vitro

This study shows that milk casein prevents black tea's ability to inactivate SARS-CoV-2 variants in vitro, suggesting milk may reduce the antiviral effect of black tea.

Why Environmental Biomarkers Work: Transcriptome-Proteome Correlations and Modeling of Multi-Stressor Experiments in the Marine Bacterium Trichodesmium

The paper examines transcriptome-proteome correlations in Trichodesmium under multi-stressor conditions, showing coherence in stress response biomarkers and discordance in metabolic pathways.

A Machine Learning Model of Microscopic Agglutination Test for Diagnosis of Leptospirosis

This paper develops a machine learning model to automate the Microscopic Agglutination Test (MAT) for leptospirosis diagnosis by improving classification accuracy using wavelet coefficient histograms.

Mechanisms and heterogeneity of mineral use by natural colonies of the cyanobacterium Trichodesmium

This study shows Trichodesmium colonies in nature process mineral particles, acquiring iron and other metals, with both beneficial and toxic effects.

Myristate can be used as a carbon and energy source for the asymbiotic growth of arbuscular mycorrhizal fungi

This study shows that myristate supports asymbiotic growth of arbuscular mycorrhizal fungi by serving as a carbon and energy source.

Temperature-dependent fasciation mutants connect mitochondrial RNA processing to the control of cell proliferation during lateral root morphogenesis

High-throughput Screening with Pluripotent Stem Cells Identifies CUDC-907 as an Effective Compound for Restoring the Proinflammatory Phenotype of Nakajo-Nishimura Syndrome

This study uses a pluripotent stem cell-derived model of Nakajo-Nishimura syndrome to identify CUDC-907 as a compound that reduces inflammatory chemokine overproduction.

GSK3 activity is a cell fate switch that balances the ratio of vascular cell type

The study identifies GSK3 activity as a cell fate switch that regulates the ratio of sieve elements to companion cells in the phloem.

PIN FORMED 2 facilitates the transport of Arsenite in Arabidopsis thaliana

This study shows PIN2 facilitates arsenite transport in Arabidopsis, leading to arsenite accumulation and root growth inhibition.

Origination of the circadian clock system in stem cells regulates cell differentiation in Arabidopsis thaliana.

The paper shows that the circadian clock in Arabidopsis stem cells regulates cell differentiation through BES1-mediated repression of LHY.

No cell is an island: circulating T cell:monocyte complexes are markers of immune perturbations

The paper identifies T cell:monocyte complexes in human blood as biological immune interactions, not technical artifacts, and shows their frequency changes with immune perturbations.

Can Human Embryonic Stem Cell-Derived Stromal Cells Serve A Starting Material For Myoblasts?

This study generates ESC-derived CD105+ stromal cells with long-term proliferation and myogenic potential as a cell source for myoblast therapy in muscular disorders.