Author

K. Wigglesworth

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:drug response / drug discovery· 1 Assay:proteomics· 1

Frequent Co-Authors

J. M. Shohet· 3 shared E. J. Rozen· 2 shared B. Sallis· 1 shared D. Moon· 1 shared E. Rozen· 1 shared G. Wang· 1 shared J. Q. Wu· 1 shared L. Huang· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersCancer Biology

J. M. Shohet

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3 papers

Recent·Most cited

Phosphorylation of MYCN and MAX by PAK family kinases is a novel tumor-suppressor mechanism in neuroblastoma with potential therapeutic implications.

E. J. Rozen, K. Wigglesworth, J. M. Shohet

The paper identifies PAK2-mediated phosphorylation of MYCN and MAX as a tumor-suppressor mechanism in neuroblastoma, with potential therapeutic strategies to restore its activity.

bioRxiv · Dec 4, 2023 · PreprintCancer Biology

A novel druggable DYRK3/CAMKV signaling module for Neuroblastoma tumor growth inhibition.

E. J. Rozen, K. Wigglesworth, J. M. Shohet

This study identifies DYRK3 and CAMKV as a signaling module critical for neuroblastoma cell proliferation and tumor growth, suggesting their inhibition as a potential therapeutic strategy.

bioRxiv · Nov 30, 2023 · PreprintCancer Biology

Protein arginine methyltransferase 5 promotes metastasis via enhancing EGFR transcription and modulating AKT1 activation by methylation

L. Huang, X.-O. Zhang, O. Verdejo-Torres, K. Wigglesworth, X. Sun, B. Sallis, D. Moon, T. Huang, E. Rozen, L. Zhang, G. Wang, J. M. Shohet, M. M. Lee, J. Q. Wu

This study shows PRMT5 promotes cancer metastasis by enhancing EGFR transcription and modulating AKT1 activation through methylation, leading to EMT and tumor cell invasion.

bioRxiv · Aug 12, 2020 · PreprintCancer Biology