X.-O. Zhang

PRMT5 orchestrates EGFR and AKT networks to activate NFκB and promote EMT

This study identifies PRMT5's role in promoting EMT in neuroblastoma by regulating EGFR and AKT pathways, leading to NFκB activation and tumor growth.

Regulation of Hedgehog Signaling Through Arih2-Mediated Smoothened Ubiquitination and Endoplasmic Reticulum-Associated Degradation

This study identifies Arih2-mediated Smo ubiquitination and ERAD as critical regulators of Hedgehog signaling, showing that Arih2{beta} prevents mislocalized Smo from disrupting pathway activity.

Programming large target genomic deletion and concurrent insertion via a prime editing-based method: PEDAR

The paper introduces PEDAR, a prime editing method that deletes and repairs genomic insertions, restoring gene function in a mouse model.

Protein arginine methyltransferase 5 promotes metastasis via enhancing EGFR transcription and modulating AKT1 activation by methylation

This study shows PRMT5 promotes cancer metastasis by enhancing EGFR transcription and modulating AKT1 activation through methylation, leading to EMT and tumor cell invasion.