ISG15 drives immune pathology and respiratory failure during viral infection
N. Shaabani, J. Zak, J. L. Johnson, Z. Huang, N. Nguyen, D. C. Lazar, V. F. Vartabedian, N. Honke, M. Prinz, K.-P. Knobeloch, K.-i. Arimoto, D.-E. Zhang, S. D. Catz, J. R. Teijaro
This study shows that lack of deISGylation during viral infection leads to immune pathology and respiratory failure, with extracellular ISG15 playing a key role in inflammation and disease severity.
bioRxiv · Apr 13, 2020 · PreprintImmunology