Author

J. Zak

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Cancer Biology· 1 Evolutionary Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:mouse· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

J. Teijaro· 3 shared I. Pratumchai· 2 shared M. Reichard· 2 shared P. Wu· 2 shared Y. Hou· 2 shared Y. Shi· 2 shared A. Cellerino· 1 shared B. Dinner· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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3 shared papersImmunology

J. Teijaro

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Transient EZH2 suppression by Tazemetostat during in vitro expansion maintains T cell stemness and improves adoptive T cell therapy

Y. Hou, J. Zak, Y. Shi, I. Pratumchai, B. Dinner, W. Wang, K. Qin, E. W. Weber, J. Teijaro, P. Wu

The paper shows that transient EZH2 inhibition with Tazemetostat during T cell expansion maintains stemness and improves adoptive T cell therapy outcomes in a murine model.

bioRxiv · Feb 7, 2023 · PreprintImmunology

Myeloid reprogramming by JAK inhibition enhances checkpoint blockade therapy

J. Zak, I. Pratumchai, B. S. Marro, K. L. Marquardt, R. Beheshti Zavareh, L. L. Lairson, M. B. A. Oldstone, J. A. Varner, V. Bachanova, J. Teijaro

Ruxolitinib reshapes myeloid immunity to synergize with checkpoint inhibitors, enhancing anti-tumor T cell activity and improving immunotherapy outcomes.

bioRxiv · Jun 24, 2022Immunology

Enhancing the anti-tumor efficacy of Bispecific T cell engagers via cell surface glycocalyx editing

Z. Yang, G. Grande, Y. Hou, C. Wang, Y. Shi, J. Zak, J. H. Cho, D. Liu, J. Teijaro, R. A. Lerner, P. Wu

This study develops BiTE-sialidase fusion proteins that enhance anti-tumor efficacy by desialylating tumor cells, improving T-cell activation and cytolysis in vitro and in vivo.

bioRxiv · May 22, 2022 · PreprintCancer Biology

The sources of sex differences in aging in annual fishes

M. Reichard, R. Blazek, J. Zak, P. Kacer, O. Tomasek, T. Albrecht, A. Cellerino, M. Polacik

This study shows that sex differences in lifespan among annual fishes are influenced by social and environmental factors rather than intrinsic aging rates.

bioRxiv · Aug 25, 2020Evolutionary Biology

ISG15 drives immune pathology and respiratory failure during viral infection

N. Shaabani, J. Zak, J. L. Johnson, Z. Huang, N. Nguyen, D. C. Lazar, V. F. Vartabedian, N. Honke, M. Prinz, K.-P. Knobeloch, K.-i. Arimoto, D.-E. Zhang, S. D. Catz, J. R. Teijaro

This study shows that lack of deISGylation during viral infection leads to immune pathology and respiratory failure, with extracellular ISG15 playing a key role in inflammation and disease severity.

bioRxiv · Apr 13, 2020 · PreprintImmunology

Performance of Turquoise killifish, model organism in aging, on commercial pelleted diet: a step towards husbandry standardization

J. Zak, I. Dykova, M. Reichard

This study shows Turquoise killifish can be weaned onto a commercial pelleted diet with comparable somatic and reproductive performance to a typical laboratory diet of frozen bloodworms.

bioRxiv · Sep 16, 2019Physiology