Author

K.-O. Chang

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Microbiology· 3

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Assay:proteomics· 1 Organism:rat· 1

Frequent Co-Authors

Y. Kim· 3 shared K. D. Perera· 2 shared S. Lovell· 2 shared W. Groutas· 2 shared C. D. McDowell· 1 shared C. Dampalla· 1 shared D. A. Meekins· 1 shared D. Bold· 1 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersMicrobiology

Y. Kim

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Potent protease inhibitors of deadly lagoviruses: rabbit hemorrhagic disease virus and European brown hare syndrome virus

K. D. Perera, D. K. Johnson, S. Lovell, W. Groutas, K.-O. Chang, Y. Kim

The paper identifies potent protease inhibitors for RHDV1, RHDV2, and EBHSV by developing assays and analyzing structure-activity relationships.

bioRxiv · Jan 10, 2022 · PreprintMicrobiology

Effects of Spike Mutations in SARS-CoV-2 Variants of Concern on Human or Animal ACE2-Mediated Virus Entry and Neutralization

Y. Kim, N. N. Gaudreault, D. A. Meekins, K. D. Perera, D. Bold, J. D. Trujillo, I. Morozov, C. D. McDowell, K.-O. Chang, J. A. Richt

This study evaluates how mutations in SARS-CoV-2 Spike protein affect viral entry and neutralization across animal ACE2 receptors and identifies key mutations that enhance viral entry and reduce antibody neutralization.

bioRxiv · Aug 25, 2021Microbiology

Post-infection treatment with a protease inhibitor increases survival of mice with a fatal SARS-CoV-2 infection

C. Dampalla, J. Zheng, K. Perera, L. Y. R. Wong, D. Meyerholz, H. Nguyen, M. Kashipathy, K. Battaile, S. Lovell, Y. Kim, S. Perlman, W. Groutas, K.-O. Chang

This study shows that post-infection treatment with a deuterated protease inhibitor improves survival and reduces viral load in mice infected with SARS-CoV-2.

bioRxiv · Feb 5, 2021Microbiology