Author

D. A. Meekins

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Microbiology· 8

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 8 Research Focus:host-pathogen & immune response· 8 Organism:mouse· 5 Assay:bulk RNA-seq· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Organism:multiple species· 1 Organism:plant (other)· 1

Frequent Co-Authors

I. Morozov· 7 shared J. A. Richt· 7 shared J. D. Trujillo· 7 shared N. N. Gaudreault· 7 shared A. Garcia-Sastre· 6 shared D. Bold· 6 shared V. Balaraman· 6 shared D. W. Madden· 5 shared

Activity by Year

2020-2021 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

7 shared papersMicrobiology

I. Morozov

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Susceptibility of sheep to experimental co-infection with the ancestral lineage of SARS-CoV-2 and its alpha variant

N. N. Gaudreault, K. Cool, J. D. Trujillo, I. Morozov, D. A. Meekins, C. D. McDowell, D. Bold, M. Carossino, V. Balaraman, D. Mitzel, T. Kwon, D. W. Madden, B. L. Artiaga, R. Pogranichniy, G. Roman-Sosa, , J. A. Richt

This study investigates sheep susceptibility to SARS-CoV-2 and finds that they show low susceptibility, with the alpha variant outcompeting the ancestral lineage.

bioRxiv · Nov 15, 2021Microbiology

Effects of Spike Mutations in SARS-CoV-2 Variants of Concern on Human or Animal ACE2-Mediated Virus Entry and Neutralization

Y. Kim, N. N. Gaudreault, D. A. Meekins, K. D. Perera, D. Bold, J. D. Trujillo, I. Morozov, C. D. McDowell, K.-O. Chang, J. A. Richt

This study evaluates how mutations in SARS-CoV-2 Spike protein affect viral entry and neutralization across animal ACE2 receptors and identifies key mutations that enhance viral entry and reduce antibody neutralization.

bioRxiv · Aug 25, 2021Microbiology

Infection and transmission of ancestral SARS-CoV-2 and its alpha variant in pregnant white-tailed deer

K. Cool, N. N. Gaudreault, I. Morozov, J. D. Trujillo, D. A. Meekins, C. McDowell, M. Carossino, D. Bold, T. Kwon, V. Balaraman, D. W. Madden, B. Libanori Artiaga, R. M. Pogranichniy, G. Roman Sosa, J. Henningson, , J. A. Richt

This study shows adult white-tailed deer are susceptible to SARS-CoV-2 and can transmit it vertically and horizontally, with the alpha variant outcompeting the ancestral strain.

bioRxiv · Aug 15, 2021Microbiology

SARS-CoV-2 variants of concern have acquired mutations associated with an increased spike cleavage

A. Escalera, A. S. Gonzalez-Reiche, S. Aslam, I. Mena, R. L. Pearl, M. Laporte, A. Fossati, R. Rathnasinghe, H. Alshammary, A. van de Guchte, M. Bouhaddou, T. Kehrer, L. Zuliani-Alvarez, D. A. Meekins, V. Balaraman, , T. Aydillo

This study shows SARS-CoV-2 variants of concern have mutations that increase spike cleavage and fusogenic capacity, enhancing viral transmission and cell entry.

bioRxiv · Aug 5, 2021 · PreprintMicrobiology

Experimental re-infected cats do not transmit SARS-CoV-2

N. N. Gaudreault, M. Carossino, I. Morozov, J. D. Trujillo, D. A. Meekins, D. W. Madden, K. Cool, B. Libanori Artiaga, C. McDowell, D. Bold, V. Balaraman, T. Kwon, W. Ma, J. Henningson, D. W. Wilson, , J. A. Richt

This study shows that SARS-CoV-2 can re-infect previously infected cats, but viral shedding is insufficient for transmission to naive cats.

bioRxiv · Jan 18, 2021Microbiology

Topoisomerase 1 inhibition therapy protects against SARS-CoV-2-induced inflammation and death in animal models.

J. S. Y. Ho, B. W.-Y. Mok, L. Campisi, T. Jordan, S. Yildiz, S. Parameswaran, J. A. Wayman, N. N. Gaudreault, D. A. Meekins, S. V. Indran, I. Morozov, J. D. Trujillo, Y. S. Fstkchyan, R. Rathnasinghe, Z. Zhu, , Jeya

This study shows that Top1 inhibition with Topotecan reduces SARS-CoV-2-induced inflammation and mortality in animal models.

bioRxiv · Dec 1, 2020 · PreprintMicrobiology

Susceptibility of swine cells and domestic pigs to SARS-CoV-2

D. A. Meekins, I. Morozov, J. D. Trujillo, N. N. Gaudreault, D. Bold, B. L. Artiaga, S. V. Indran, T. Kwon, V. Balaraman, D. W. Madden, H. Feldmann, J. Henningson, W. Ma, U. B. R. Balasuriya, J. A. Richt

This study assesses SARS-CoV-2 susceptibility in swine cells and pigs, finding replication in cell lines but no infection or transmission in pigs.

bioRxiv · Aug 15, 2020Microbiology

SARS-CoV-2 infection, disease and transmission in domestic cats

N. N. Gaudreault, J. D. Trujillo, M. Carossino, D. A. Meekins, I. Morozov, D. W. Madden, S. V. Indran, D. Bold, V. Balaraman, T. Kwon, B. Libanori Artiaga, K. Cool, A. Garcia-Sastre, W. Ma, W. C. Wilson, , J. A. Richt

This study investigates SARS-CoV-2 infection, disease progression, and transmission in domestic cats through experimental challenge and monitoring.

bioRxiv · Aug 4, 2020Microbiology