This study investigates sheep susceptibility to SARS-CoV-2 and finds that they show low susceptibility, with the alpha variant outcompeting the ancestral lineage.

bioRxiv · Nov 15, 2021Microbiology

Effects of Spike Mutations in SARS-CoV-2 Variants of Concern on Human or Animal ACE2-Mediated Virus Entry and Neutralization

Y. Kim, N. N. Gaudreault, D. A. Meekins, K. D. Perera, D. Bold, J. D. Trujillo, I. Morozov, C. D. McDowell, K.-O. Chang, J. A. Richt

This study evaluates how mutations in SARS-CoV-2 Spike protein affect viral entry and neutralization across animal ACE2 receptors and identifies key mutations that enhance viral entry and reduce antibody neutralization.

bioRxiv · Aug 25, 2021Microbiology

Infection and transmission of ancestral SARS-CoV-2 and its alpha variant in pregnant white-tailed deer

K. Cool, N. N. Gaudreault, I. Morozov, J. D. Trujillo, D. A. Meekins, C. McDowell, M. Carossino, D. Bold, T. Kwon, V. Balaraman, D. W. Madden, B. Libanori Artiaga, R. M. Pogranichniy, G. Roman Sosa, J. Henningson, , J. A. Richt

This study shows adult white-tailed deer are susceptible to SARS-CoV-2 and can transmit it vertically and horizontally, with the alpha variant outcompeting the ancestral strain.

bioRxiv · Aug 15, 2021Microbiology

Experimental re-infected cats do not transmit SARS-CoV-2

N. N. Gaudreault, M. Carossino, I. Morozov, J. D. Trujillo, D. A. Meekins, D. W. Madden, K. Cool, B. Libanori Artiaga, C. McDowell, D. Bold, V. Balaraman, T. Kwon, W. Ma, J. Henningson, D. W. Wilson, , J. A. Richt

This study shows that SARS-CoV-2 can re-infect previously infected cats, but viral shedding is insufficient for transmission to naive cats.

bioRxiv · Jan 18, 2021Microbiology

Topoisomerase 1 inhibition therapy protects against SARS-CoV-2-induced inflammation and death in animal models.

J. S. Y. Ho, B. W.-Y. Mok, L. Campisi, T. Jordan, S. Yildiz, S. Parameswaran, J. A. Wayman, N. N. Gaudreault, D. A. Meekins, S. V. Indran, I. Morozov, J. D. Trujillo, Y. S. Fstkchyan, R. Rathnasinghe, Z. Zhu, , Jeya

This study shows that Top1 inhibition with Topotecan reduces SARS-CoV-2-induced inflammation and mortality in animal models.

bioRxiv · Dec 1, 2020 · PreprintMicrobiology

Susceptibility of swine cells and domestic pigs to SARS-CoV-2

D. A. Meekins, I. Morozov, J. D. Trujillo, N. N. Gaudreault, D. Bold, B. L. Artiaga, S. V. Indran, T. Kwon, V. Balaraman, D. W. Madden, H. Feldmann, J. Henningson, W. Ma, U. B. R. Balasuriya, J. A. Richt

This study assesses SARS-CoV-2 susceptibility in swine cells and pigs, finding replication in cell lines but no infection or transmission in pigs.

bioRxiv · Aug 15, 2020Microbiology

SARS-CoV-2 infection, disease and transmission in domestic cats

N. N. Gaudreault, J. D. Trujillo, M. Carossino, D. A. Meekins, I. Morozov, D. W. Madden, S. V. Indran, D. Bold, V. Balaraman, T. Kwon, B. Libanori Artiaga, K. Cool, A. Garcia-Sastre, W. Ma, W. C. Wilson, , J. A. Richt

This study investigates SARS-CoV-2 infection, disease progression, and transmission in domestic cats through experimental challenge and monitoring.

bioRxiv · Aug 4, 2020Microbiology