Acidosis Licenses the NLRP3 Inflammasome-Inhibiting Effects of Beta-Hydroxybutyrate and Short-Chain Carboxylic Acids
Madeleine M. Mank, Kaitlyn A Zoller, V. Amanda Fastiggi, Jennifer L. Ather, Matthew E. Poynter
This study shows that BHB and SCCAs inhibit NLRP3 inflammasome activation under acidic conditions, mediated by GPR41/FFAR3, suggesting their potential as anti-inflammatory agents during metabolic stress.
bioRxiv · May 1, 2025 · PreprintImmunology