Matthew E. Poynter

This study develops a novel mouse model of human lung cancer cachexia that exhibits early adipose tissue wasting and metabolic reprogramming, mirroring human disease features.

This study shows that BHB and SCCAs inhibit NLRP3 inflammasome activation under acidic conditions, mediated by GPR41/FFAR3, suggesting their potential as anti-inflammatory agents during metabolic stress.

This study shows beta-hydroxybutyrate inhibits bronchial smooth muscle contraction in vitro and ex vivo, suggesting it could be a therapeutic agent for asthma.

This study shows that beta-hydroxybutyrate reduces pro-inflammatory cytokine production in bronchial smooth muscle cells by activating FFAR3.