V. Amanda Fastiggi

This study develops a bioprinted artery-on-a-chip model to study inflammatory responses and test drug efficacy in human arteries.

This study shows that BHB and SCCAs inhibit NLRP3 inflammasome activation under acidic conditions, mediated by GPR41/FFAR3, suggesting their potential as anti-inflammatory agents during metabolic stress.

This study shows beta-hydroxybutyrate inhibits bronchial smooth muscle contraction in vitro and ex vivo, suggesting it could be a therapeutic agent for asthma.

This study shows that beta-hydroxybutyrate reduces pro-inflammatory cytokine production in bronchial smooth muscle cells by activating FFAR3.