Regulation of excitatory presynaptic activity by Ambra1 protein determines neuronal networks in sex-dimorphic manner
Anes Ju, Bekir Altas, Hong Jun Rhee, Manuela Schwark, Imam A. Hassouna, Albrecht Sigler, Hiroshi Kawabe, Kamal Chowdhury, Hannelore Ehrenreich, Nils Brose, JeongSeop Rhee
This study shows that Ambra1 heterozygosity causes sex-specific reductions in excitatory synaptic activity, leading to E/I imbalance and autism-like behaviors in female mice.
bioRxiv · Dec 19, 2022 · PreprintNeuroscience