Karl Heinz Plate

This study benchmarks cell-type deconvolution methods across cross-platform transcriptomic data, finding that log-normal regression methods like SpatialDecon perform most reliably.

The paper identifies tertiary lymphoid structures in gliomas as sites of immune response, showing they correlate with better survival and involve T and B cell clonal expansion and plasma cell formation.

The paper identifies tertiary lymphoid structures in brain metastases from different cancer types and links their presence to patient survival.

The paper uses single-cell sequencing and spatial transcriptomics to compare immune responses in leptomeningeal disease with other CNS disorders, identifying disease-specific immune environments and progression mechanisms.

This study shows that blocking ATP-to-adenosine enzymes and combining with radiotherapy improves anti-cancer immunity in brain metastases by altering immune cell populations and tumor inflammation.

This study identifies LINC00607 as an endothelial-specific lncRNA that supports angiogenic function by interacting with BRG1 to regulate chromatin accessibility and ERG target gene transcription.