Paula Nieto

Multi-omic profiling of pleural effusions: a reservoir-incubator for non-invasive insights into tumor heterogeneity

This study presents the first comprehensive single-cell and multi-omic atlas of pleural effusions, revealing disease-specific immune landscapes and tumor heterogeneity.

Decoding the immune response in leptomeningeal disease through single-cell sequencing of cerebrospinal fluid

The paper uses single-cell sequencing and spatial transcriptomics to compare immune responses in leptomeningeal disease with other CNS disorders, identifying disease-specific immune environments and progression mechanisms.

Single cell analysis reveals the impact of age and maturation stage on the human oocyte transcriptome

This study analyzes the transcriptomes of human oocytes at different maturation stages and finds that age affects specific gene pathways in matured oocytes.

SPOTlight:Seeded NMF regression to Deconvolute Spatial Transcriptomics Spots with Single-Cell Transcriptomes

SPOTlight integrates spatial transcriptomics with single-cell RNA-seq to deconvolute cell types and states in tissues, showing accurate predictions in mouse brain and human pancreatic cancer.