Sensory lesioning induces microglial synapse elimination via ADAM10 and fractalkine signaling
Georgia Gunner, Lucas Cheadle, Kasey M. Johnson, Pinar Ayata, Ana Badimon, Erica Mondo, M. Aurel Nagy, Liwang Liu, Shane M. Bemiller, Ki-Wook Kim, Sérgio A. Lira, Bruce T. Lamb, Andrew R. Tapper, Richard M. Ransohoff, Michael E. Greenberg, , Dorothy P. Schafer
This study shows that sensory lesioning causes microglia to eliminate synapses through ADAM10 and fractalkine signaling, revealing a neuron-to-microglia pathway for synaptic remodeling.
Nature Neuroscience · Jun 17, 2019Peer-reviewedNeuroscience