Kate M. Brown

The Yersinia pestis virulence effector YopM binds the human pyrin death domain to inhibit inflammasome activation and effector-triggered immunity

This paper identifies how Yersinia pestis YopM binds the human pyrin death domain to inhibit inflammasome activation and shows that this interaction is critical for its virulence.

Biochemical characterization of Bacillus anthracis sortase B: Use in sortase mediated ligation and substrate recognition dependent on residues beyond the canonical pentapeptide binding motif for sortase enzymes

This study characterizes Bacillus anthracis SrtB, showing that residues outside the canonical pentapeptide motif are critical for activity and that engineered variants can improve ligation efficiency.