Author

Adam R. Simard

Dartmouth CollegeORCID 0000-0001-8175-1196Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:bacteria (other)· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Approach:statistical model· 1

Frequent Co-Authors

Dean R. MaddeniD· 2 shared Akaash Kumar MishraiD· 1 shared Andrew P. Hederman· 1 shared Ao LiuiD· 1 shared Bethany W. MwauraiD· 1 shared Christophe H.P. MorisseauiD· 1 shared James B. BliskaiD· 1 shared Kate M. Brown· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersBiochemistry

Dean R. MaddenORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

BiochemistryJournal of Structural Biology XPeer-reviewedSep 30, 2026

Convergent strategies for nanobody-mediated inhibition of an epoxide hydrolase

Adam R. Simard, Noor M Taher, Kathryn S. Beauchemin…·Dean R. Madden

The paper identifies two classes of nanobodies that inhibit Cif, an epoxide hydrolase from Pseudomonas aeruginosa, through distinct structural strategies targeting a shared epitope.

DOI 10.1016/j.yjsbx.2026.100166

bacteria (other)protein structure

𝕏 PostBluesky

MicrobiologybioRxivPreprintJun 9, 2026

The Yersinia pestis virulence effector YopM binds the human pyrin death domain to inhibit inflammasome activation and effector-triggered immunity

Bethany W. Mwaura, Adam R. Simard, Kate M. Brown…·James B. Bliska

This paper identifies how Yersinia pestis YopM binds the human pyrin death domain to inhibit inflammasome activation and shows that this interaction is critical for its virulence.

DOI 10.64898/2026.02.25.707193

humanexperimental assay

𝕏 PostBluesky