Gut microbiome derived folate metabolite suppresses colorectal cancer progression
Rebecca Danner, Juyeong Cho, Zachary Detwiler, Jonathan Williams, Jiyoung Amanda Han, Chang Yang, Xavier Diebold, Katerina Maeder, Jonathan G. Van Vranken, Allison S. Walker, Cammie F. Lesser, Snehal N. Chaudhari
The paper shows that gut microbiota-derived folinic acid suppresses colorectal cancer progression by inhibiting calpain-2 and stabilizing E-cadherin.
bioRxiv · Jul 15, 2026 · PreprintCancer Biology