Jonathan G. Van Vranken

Folic acid polyglutamylation triggers MAP2K5 signaling to induce adipocyte lipid catabolism

This study shows that folic acid polyglutamylation activates MAP2K5 signaling to promote adipocyte lipid breakdown, revealing a novel role for folate in lipid homeostasis.

Gut microbiome derived folate metabolite suppresses colorectal cancer progression

The paper shows that gut microbiota-derived folinic acid suppresses colorectal cancer progression by inhibiting calpain-2 and stabilizing E-cadherin.

SLC16A6 is a tyrosine transporter for the melanosome

This study identifies SLC16A6 as the melanosomal tyrosine transporter, showing it is essential for melanosome biogenesis and function.

Lineage specifying transcription factors determine cell function by direct control of metabolism

The paper identifies lineage-specifying transcription factors that directly control metabolism to ensure cell function.

Microbial metabolism of methotrexate produces a STAT3 signaling molecule that alleviates gut inflammation

The paper identifies a gut microbial metabolite of methotrexate that alleviates gut inflammation by promoting mitochondrial STAT3 signaling.

On-target toxicity limits the efficacy of CDK11 inhibition against cancers with 1p36 deletions

This study shows CDK11 is critical for cancer cell survival and identifies 1p36 deletions as a biomarker for CDK11 inhibitor sensitivity, but on-target toxicity limits therapeutic efficacy.

Interrupting ELMSAN1 repression of nuclear Acetyl-CoA production therapeutically reprograms cancer cells

The paper identifies ELMSAN1 as a repressor of nuclear acetyl-CoA production and shows that inhibiting this interaction reprograms cancer cells to a postmitotic state, improving survival in multiple cancer models.

Ergothioneine boosts mitochondrial respiration and exercise performance via direct activation of MPST

This study identifies MPST as the direct target of EGT, showing it enhances mitochondrial respiration and exercise performance in mice.