Folic acid polyglutamylation triggers MAP2K5 signaling to induce adipocyte lipid catabolism
Woo Sung Kim, Rebecca Danner, Juyeong Cho, Jonathan Williams, Luiz Lopez, Yutong Bao, Julia K. Hansen, Elizabeth M. Poad, Haania Khan, Daehan Kim, Brian W. Parks, Jonathan G. Van Vranken, David A. Harris, Andrea Galmozzi, Mary‐Elizabeth Patti, Snehal N. Chaudhari
This study shows that folic acid polyglutamylation activates MAP2K5 signaling to promote adipocyte lipid breakdown, revealing a novel role for folate in lipid homeostasis.
bioRxiv · Sep 17, 2026 · PreprintBiochemistry