Structure and function of yeast Lso2 and human CCDC124 bound to hibernating ribosomes.
Jennifer N. Wells, Robert Buschauer, Timur Mackens‐Kiani, Katharina Best, Hanna Kratzat, Otto Berninghausen, Thomas A. Becker, Wendy V. Gilbert, Jingdong Cheng, Roland Beckmann
The paper presents cryo-EM structures of hibernating yeast and human ribosomes, showing Lso2/CCDC124 binds in a non-rotated state, enabling rapid translation reactivation.
PLoS Biology · Jul 20, 2020Peer-reviewedMolecular Biology