Restoring Antibiotic Sensitivity via Metabolic Pathway Manipulation in Pseudomonas aeruginosa
Hannah M. Doherty, Jennifer van der Laan, Daniel Martínez‐Martínez, Theresa Fink, Katharina Stanzel, Huda Ahmad, Leonie Helfer, Ivan Andrew, Laurence Gamé, Iliyana Kaneva, Alex Montoya, Holger Kramer, João Benhur Mokochinski, Susanne Brodesser, Ignacio Sottorff, , Filipe Cabreiro
The paper shows that combining biotin biosynthesis inhibition with metformin reduces Pseudomonas aeruginosa virulence and restores antibiotic sensitivity by targeting metabolic pathways.
bioRxiv · Oct 4, 2026 · PreprintMicrobiology