Author

Leonie Helfer

University of Cologne

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Assay:metabolomics· 1 Assay:proteomics· 1

Frequent Co-Authors

Alex MontoyaiD· 1 shared Daniel Martínez‐MartíneziD· 1 shared Erwin BohniD· 1 shared Filipe CabreiroiD· 1 shared Hannah M. DohertyiD· 1 shared Holger KrameriD· 1 shared Huda AhmadiD· 1 shared Ignacio SottorffiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperMicrobiology

Alex MontoyaORCID

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1 paper

Recent·Most cited

Restoring Antibiotic Sensitivity via Metabolic Pathway Manipulation in Pseudomonas aeruginosa

Hannah M. Doherty, Jennifer van der Laan, Daniel Martínez‐Martínez, Theresa Fink, Katharina Stanzel, Huda Ahmad, Leonie Helfer, Ivan Andrew, Laurence Gamé, Iliyana Kaneva, Alex Montoya, Holger Kramer, João Benhur Mokochinski, Susanne Brodesser, Ignacio Sottorff, , Filipe Cabreiro

The paper shows that combining biotin biosynthesis inhibition with metformin reduces Pseudomonas aeruginosa virulence and restores antibiotic sensitivity by targeting metabolic pathways.

bioRxiv · Oct 4, 2026 · PreprintMicrobiology