Susanne Brodesser

This study identifies bacterial enterobactin as a non-canonical neurotransmitter that modulates host behavior and aging via mitochondrial function and redox state.

The paper shows that combining biotin biosynthesis inhibition with metformin reduces Pseudomonas aeruginosa virulence and restores antibiotic sensitivity by targeting metabolic pathways.

This study shows mitochondrial dysfunction accelerates aging by disrupting gut microbiota structure and inducing immune dysregulation and inflammation through metabolic reprogramming.

The paper investigates the pathogenic mutation m.10191T>C in mitochondrial DNA, showing it leads to reduced complex I function and NADH accumulation, contributing to Leigh syndrome.

This study identifies ERLIN1/2 scaffolds that mediate TMUB1-RNF170 interactions, regulate cholesterol esterification, and maintain ER cholesterol levels to control Golgi morphology and the secretory pathway.

This study identifies CerS4's role in regulating hair follicle stem cell niche formation through sphingolipid metabolism, impacting skin homeostasis and barrier function.