Lysophosphatidylcholine induces heat pain hypersensitivity in obese mice fed with a high-fat diet through activation of peripheral Acid-Sensing Ion Channel 3
Ahmed Negm, Katharina Stobbe, Lucile Fleuriot, Delphine Debayle, Emmanuel Deval, Éric Lingueglia, Carole Rovère, Jacques Noël
This study shows that high-fat diet-induced obesity in mice increases heat pain hypersensitivity via lysophosphatidylcholine activation of ASIC3 channels in dorsal root ganglia neurons.
bioRxiv · Dec 7, 2021 · PreprintNeuroscience