Éric Lingueglia

The paper identifies two synthetic peptides that potently and selectively modulate ASIC3 activity, showing similar effects but differing in washout kinetics.

This study investigates the role of T-type calcium channel Cav3.2 in PKCγ neurons of the spinal dorsal horn during chronic pain, showing its involvement in synaptic and intrinsic activity changes but not in firing properties.

This study shows ASIC1a/ASIC2 channels in spinal neurons contribute to pain processing by modulating windup through calcium-dependent mechanisms.

The paper investigates how lysophosphatidyl-choline (LPC) induces pain via ASIC3-dependent mechanisms in spinal cord nociceptive pathways.

The paper identifies LPC16:0 as a mediator of chronic joint pain through ASIC3, supported by preclinical and clinical evidence.

This study shows that high-fat diet-induced obesity in mice increases heat pain hypersensitivity via lysophosphatidylcholine activation of ASIC3 channels in dorsal root ganglia neurons.

This study identifies JNK as a post-translational regulator of ASIC1b and ASIC3 channels in sensory neurons, showing its role in pain hypersensitivity.