Inhibitory regulation of calcium transients in prefrontal dendritic spines is compromised by a nonsense Shank3 mutation
Farhan Ali, Ling-Xiao Shao, Danielle M. Gerhard, Katherine Sweasy, Santosh Pothula, Christopher Pittenger, Ronald S. Duman, Alex C. Kwan
This study shows that a Shank3 mutation causes elevated calcium in dendritic spines due to reduced inhibition from SST interneurons, and correcting this improves learning deficits.
Molecular Psychiatry · Mar 11, 2020Peer-reviewedNeuroscience