Alex C. Kwan

This study shows psilocybin increases dendritic calcium activity in mice during quiet wakefulness, dependent on 5-HT2A receptors, and disrupts the link between calcium signaling and spine formation.

This study shows psilocybin increases dendritic spine density and improves fear extinction in chronically stressed mice.

This study shows psilocybin selectively affects GABAergic interneurons in the mouse medial frontal cortex, reducing somatostatin-expressing and increasing parvalbumin-expressing neuron activity.

This study combines psilocybin with a PDE9 inhibitor to reduce head-twitch response and alter synaptic proteome while preserving antidepressant effects.

This study shows psilocybin alters large-scale cortical network connectivity in mice by strengthening inputs from perceptual and medial regions and weakening cortico-cortical loops, dependent on drug-evoked spiking activity.

This study shows that Scn2a haploinsufficiency impairs dendritic signaling and flexible decision-making in mice.

This study shows psilocybin prolongs neurovascular coupling in mouse visual cortex, affecting blood flow without altering neural responses, and suggests implications for interpreting human neuroimaging data.

This study uses two-photon microscopy to show that NE and ACh transients have distinct spatiotemporal dynamics during decision-making in mice, with NE promoting exploration.

The paper classifies psychedelics and psychoactive drugs using brain-wide imaging of c-Fos expression and machine learning, achieving above-chance accuracy in drug identification.

This study uses single-nucleus RNA sequencing to show psilocybin and ketamine induce cell type-specific and time-dependent gene expression changes in mouse medial frontal cortex neurons.

This study identifies specific pyramidal cell types and 5-HT2A receptors in the medial frontal cortex as essential for psilocybin's long-term therapeutic effects.

This study investigates how psilocybin affects fear extinction in mice, finding that dose, context, and serotonin receptors are critical factors.

The paper investigates how spatiotemporal dynamics of norepinephrine release in the prefrontal cortex affect neuronal firing and finds that local NE fields can drive cell firing independently of global fields during decoupling.

The paper investigates how cholinergic systems contribute to changes in brain functional connectivity during nicotine withdrawal in male mice, identifying two distinct long-range cholinergic networks and associated genes.

This study investigates the behavioral and neural effects of 5-MeO-DMT in mice, showing dose-dependent changes in behavior and long-term dendritic spine density increases without affecting spine size.

This study maps brain regions with drug-induced c-Fos expression after psilocybin and ketamine in mice, revealing shared and distinct patterns linked to glutamatergic receptors.

GESIAP is a MATLAB-based image analysis program that processes genetically encoded sensor data to analyze neuromodulator transmission properties across cell types and species.

This study shows mice can anticipate environmental changes during reward learning, with the medial frontal cortex playing a key role in estimating future change points.

This study shows that pupil size in mice playing a competitive game correlates with decision variables like choice, outcome, and value updating, but not action selection.

The paper introduces a database and deep learning tool for spike inference from calcium imaging data, outperforming existing methods with an automated, parameter-free algorithm.

This study shows psilocybin rapidly and persistently increases dendritic spine size and density in mouse frontal cortex, with lasting behavioral and neurophysiological effects.

This study examines how repeated social stress affects reward behavior and prefrontal cortical activity in mice, showing that neural responses diverge over time between resilient and susceptible animals.

This study shows that a Shank3 mutation causes elevated calcium in dendritic spines due to reduced inhibition from SST interneurons, and correcting this improves learning deficits.

This study shows that ketamine suppresses SST interneurons, leading to increased calcium signals in dendritic spines of pyramidal neurons in the medial prefrontal cortex of awake mice.

The paper investigates how reward influences neural coding of choices in the mouse medial frontal cortex during a task with probabilistic outcomes.