Ling-Xiao Shao

This study shows psilocybin increases dendritic calcium activity in mice during quiet wakefulness, dependent on 5-HT2A receptors, and disrupts the link between calcium signaling and spine formation.

This study shows psilocybin selectively affects GABAergic interneurons in the mouse medial frontal cortex, reducing somatostatin-expressing and increasing parvalbumin-expressing neuron activity.

This study shows psilocybin alters large-scale cortical network connectivity in mice by strengthening inputs from perceptual and medial regions and weakening cortico-cortical loops, dependent on drug-evoked spiking activity.

The paper classifies psychedelics and psychoactive drugs using brain-wide imaging of c-Fos expression and machine learning, achieving above-chance accuracy in drug identification.

This study identifies specific pyramidal cell types and 5-HT2A receptors in the medial frontal cortex as essential for psilocybin's long-term therapeutic effects.

This study maps brain regions with drug-induced c-Fos expression after psilocybin and ketamine in mice, revealing shared and distinct patterns linked to glutamatergic receptors.

This study shows psilocybin rapidly and persistently increases dendritic spine size and density in mouse frontal cortex, with lasting behavioral and neurophysiological effects.

This study shows that a Shank3 mutation causes elevated calcium in dendritic spines due to reduced inhibition from SST interneurons, and correcting this improves learning deficits.