Author

Kathrin Hacker

University of Vienna

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Approach:statistical model· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Daniel B. GrabarczykiD· 2 shared Gijs A. VersteegiD· 2 shared Julian F. EhrmanniD· 2 shared Tim ClauseniD· 2 shared Valentina BudroniiD· 2 shared Alexandra ShulkinaiD· 1 shared Ariane MandlbaueriD· 1 shared David HaselbachiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersCell Biology

Daniel B. GrabarczykORCID

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2 papers

Recent·Most cited

Guardian ubiquitin E3 ligases target cancer-associated APOBEC3 deaminases for degradation to promote human genome integrity.

Irene Schwartz, Valentina Budroni, Mathilde Meyenberg, Zuzana Hodáková, Harald Hornegger, Kathrin Hacker, Siegfried Schwartz, Daniel B. Grabarczyk, Julian F. Ehrmann, Sara Scinicariello, David Haselbach, Jörg Menche, Tim Clausen, Gülsün Elif Karagöz, Gijs A. Versteeg

The paper identifies UBR4, UBR5, and HUWE1 as E3 ligases that degrade cancer-associated APOBEC3 proteins to prevent genome mutagenesis.

Nature Communications · Jan 19, 2026Peer-reviewedCell Biology

TRIM52 is a primate-specific player in the DNA repair process under tight proteolytic control by a triad of giant E3 ligases

Alexandra Shulkina, Kathrin Hacker, Julian F. Ehrmann, Valentina Budroni, Ariane Mandlbauer, Johannes Bock, Daniel B. Grabarczyk, Luisa Cochella, Tim Clausen, Gijs A. Versteeg

The paper identifies TRIM52 as a primate-specific DNA repair factor under tight proteolytic control by BIRC6, HUWE1, and UBR4/KCMF1.

bioRxiv · May 16, 2024 · PreprintMolecular Biology