Bioisosteric analogs of MDMA with improved pharmacological profile
Ana Sofia Alberto‐Silva, Selina Hemmer, Hailey A. Bock, Letícia Alves da Silva, Kenneth R. Scott, Nina Kastner, Manan Bhatt, Marco Niello, Kathrin Jäntsch, Oliver Kudlacek, Elena Bossi, Thomas Stockner, Markus Robert Meyer, John D. McCorvy, Simon D. Brandt, , Harald H. Sitte
This study evaluates three MDMA bioisosteres for improved pharmacological profiles, finding reduced off-target receptor activity and altered hepatic metabolism compared to MDMA.
Journal of Neurochemistry · Jun 19, 2024Peer-reviewedPharmacology & Toxicology