Author

Elena Bossi

University of InsubriaORCID 0000-0002-9549-2153Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 4 Plant Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:mouse· 3 Research Focus:cell type annotation· 2 Assay:proteomics· 2 Organism:Arabidopsis· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Angela Di IacovoiD· 3 shared Cristina RosetiiD· 2 shared Guido DomingoiD· 2 shared Laura CivieroiD· 2 shared Ludovica IovinoiD· 2 shared Algerta MarkuiD· 1 shared Ana Sofia Alberto‐SilvaiD· 1 shared Andre BazzoneiD· 1 shared

Activity by Year

2021-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersNeuroscience

Angela Di IacovoORCID

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

LRRK2 G2019S disrupts GABAergic signaling and shifts excitatory/inhibitory balance in the striatum

Angela Di Iacovo, Giuseppe Aceto, Ludovica Iovino, Roberta De Rosa, Raffaella Cinquetti, Charlotte Kilstrup‐Nielsen, Tiziana Alberio, Marcello D’Ascenzo, Laura Civiero, Elena Bossi, Cristina Roseti

This paper shows that the LRRK2 G2019S mutation reduces GABA-evoked currents and disrupts the excitatory/inhibitory balance in the striatum.

bioRxiv · Oct 23, 2025 · PreprintNeuroscience

Delineating plant responses to the 3',5'- and 2',3'-cAMP isomers

Eleonora Davide, Guido Domingo, Angela Di Iacovo, Milena Marsoni, Ping Yun, Chris Gehring, Elena Bossi, Sergey N. Shabala, Marcella Bracale, Candida Vannini

The paper investigates isomer-specific responses of 3',5'- and 2',3'-cAMP in Arabidopsis, revealing distinct proteomic and physiological effects.

bioRxiv · Oct 9, 2025 · PreprintPlant Biology

Unveiling the crucial role of betaine: Modulation of GABA homeostasis via SLC6A1 transporter (GAT1)

Manan Bhatt, Erika Lazzarin, Ana Sofia Alberto‐Silva, Guido Domingo, Rocco Zerlotti, Ralph Gradisch, Andre Bazzone, Harald H. Sitte, Thomas Stockner, Elena Bossi

This study identifies betaine as a slow substrate of GAT1, showing it modulates GABA reuptake and helps maintain GABA homeostasis, protecting neurons from excitotoxicity.

Cellular and Molecular Life Sciences · Jun 17, 2024Peer-reviewedNeuroscience

Trafficking of the glutamate transporter is impaired in LRRK2-related Parkinson's disease

Ludovica Iovino, Veronica Giusti, Francesca Pischedda, Elena Giusto, Nicoletta Plotegher, Antonella Marte, Ilaria Battisti, Angela Di Iacovo, Algerta Marku, Giovanni Piccoli, Rina Bandopadhyay, Carla Perego, Tiziana Bonifacino, Giambattista Bonanno, Cristina Roseti, , Laura Civiero

This study shows that the LRRK2 G2019S mutation impairs EAAT2 trafficking, leading to reduced glutamate clearance and potential neurodegeneration in Parkinson's disease.

Acta Neuropathologica · May 21, 2022Peer-reviewedNeuroscience

Bile acids gate dopamine transporter mediated currents

Tiziana Romanazzi, Daniele Zanella, Mary Hongying Cheng, Behrgen Smith, Angela M. Carter, Aurelio Galli, İvet Bahar, Elena Bossi

This study investigates how bile acid obeticholic acid (OCA) interacts with the dopamine transporter (DAT) and modulates its activity through non-competitive binding mechanisms.

Frontiers in Chemistry · Dec 10, 2021Peer-reviewedNeuroscience