Antibiotics modulate activity of mouse and human dorsal root ganglia neurons
Ashley N. Plumb, Joseph B. Lesnak, Jane M Brandon, Lucia M Cardona, Mackenzie A Simms, McKenna L. Pratt, Katie T. Ward, Kevin Joseph Tidgewell, Gregory O. Dussor, Theodore John Price, Katelyn E. Sadler
The paper shows that antibiotics like β-lactams, macrolides, and tetracyclines alter calcium flux in DRG neurons through mechanisms involving extracellular calcium, TRPA1, and mitochondrial ROS.
bioRxiv · Sep 16, 2026 · PreprintNeuroscience