Author

Kevin Joseph Tidgewell

University of KentuckyORCID 0000-0002-0501-2604Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Assay:electronic health records· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Benedict James KolberiD· 2 shared Christian Kuete FofiéiD· 2 shared Rebekah D. SimcikiD· 2 shared Andrea Hough· 1 shared Asef FarukiD· 1 shared Ashley N. PlumbiD· 1 shared Eduardo J. E. Caro‐DiaziD· 1 shared Gregory O. DussoriD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersNeuroscience

Benedict James KolberORCID

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Author profile →

3 papers

Recent·Most cited

Antibiotics modulate activity of mouse and human dorsal root ganglia neurons

Ashley N. Plumb, Joseph B. Lesnak, Jane M Brandon, Lucia M Cardona, Mackenzie A Simms, McKenna L. Pratt, Katie T. Ward, Kevin Joseph Tidgewell, Gregory O. Dussor, Theodore John Price, Katelyn E. Sadler

The paper shows that antibiotics like β-lactams, macrolides, and tetracyclines alter calcium flux in DRG neurons through mechanisms involving extracellular calcium, TRPA1, and mitochondrial ROS.

bioRxiv · Sep 16, 2026 · PreprintNeuroscience

Neurobiological and Chemical Characterization of the Cyanobacterial Metabolite Veraguamide E

Jesus E. Sotelo-Morales, Sahar Mofidi Tabatabaei, Christian Kuete Fofié, Kelvin K. Fosu, Joseph Dodd‐o, Rebekah D. Simcik, See Hyun Tack, Miguel J. Soto-Reyes, Muhammad Saad Yousuf, Eduardo J. E. Caro‐Diaz, Vivek Kumar, Wade D. Van Horn, Benedict James Kolber, Kevin Joseph Tidgewell

This paper characterizes the cyanobacterial metabolite Veraguamide E, showing it binds the sigma-2 receptor with high affinity, modulates calcium signaling in neurons, and lacks cytotoxicity.

Journal of Natural Products · Nov 6, 2025Peer-reviewedNeuroscience

Isolation and Bioassay of Linear Veraguamides from a Marine Cyanobacterium (Okeania sp.)

Stacy‐Ann J. Parker, Andrea Hough, Thomas D. Wright, Neil C. Lax, Asef Faruk, Christian Kuete Fofié, Rebekah D. Simcik, Jane E. Cavanaugh, Benedict James Kolber, Kevin Joseph Tidgewell

This paper isolates and evaluates three veraguamide analogs from a marine cyanobacterium, finding one shows cytotoxicity against triple-negative breast cancer cells and affinity for the sigma2 receptor.

Molecules · Feb 4, 2025Peer-reviewedCancer Biology